Investigation of Dose Effect of ICRP110 Male and Female Head Phantoms During BNCT and PBFT by Monte Carlo Simulations

H. Korkut, T. Korkut, V. P. Singh

Abstract


Boron Neutron Capture Therapy (BNCT) and Proton Boron Fusion Therapy (PBFT) are of great interest in the field of radiation oncology. These treatment methods may offer different advantages and disadvantages depending on the type of tissue involved, as well as the location and size of the cancerous area. In this study, radiation dose effect of BNCT and PBFT on the brain, one of the most sensitive organs of the human body, was examined comparatively, based on the ICRP110 male and female head phantom models by using GEANT4 Monte Carlo simulations. Additionally, some necessary LET (Linear Energy Transfer) calculations are also presented in the article. Dose, LET and Energy deposition values of GEANT4 calculations were presented for BNCT and PBFT therapies in details for male and female phanthom comparatively.

Keywords


BNCT; PBFT; Brain; Geant4; Radiation Dose; LET; (Linear Energy Transfer)

Full Text:

PDF

References


International Atomic Energy Agency (IAEA), Advances in Boron Neutron Capture Therapy, Vienna, 2023.

H. He, J. Li, P. Jiang et al., Radiat Oncol. 16 (2021) 216.

T. D. Malouff, D. S. Seneviratne, D. K. Ebner et al., Front. Oncol. 11 (2021) 601820.

M. Kaur, R. Meena, K. Nishimura et al., Inorg. Chem.Commun. 157 (2023) 111318.

S. Namdev and G. Kaur, A Mini Review on Application of Boron Neutron Capture Therapy in Cancer Treatmen, in: IOP Conference Series: Materials Science and Engineering (2022) 012047.

R. Kayama, K. Tsujino, S. Kawabata et al., Sci. Rep. 14 (2024) 8265.

TAE Life Sciences, Developing targeted drugs for boron neutron capture therapyto treat refractory cancers, https://www.nature.com/biopharmdeal. Retrieved in March (2021).

S. Savolainen, M. Kortesniemi, M. Timonen et al., Phys. Med. 29 (2013) 233.

A. S. Elyutina, W.S . Kiger III and A. A. Portnov, Appl. Radiat. Isot. 69(2011) 1888.

S. Belousov, M. Mitev, K. Ilieva et al., Appl. Radiat. Isot. 69 (2011) 1936.

W. S. Kiger III, X. Q. Lu, O. K. Harling et al., Appl. Radiat.Isot. 61 (2004) 1075.

J. Y. Jung, B. Lu, D. K. Yoon et al. Phys. Med. 32 (2016) 562.

J. Y. Jung, D. K. Yoon, B. Barraclough et al., Oncotarget 8 (2017) 39774.

V. Istokskaia, M. Tosca, L. Giuffrida et al., Commun. Phys. 6 (2023) 27.

K. Batani, J. Instrum. 18 (2023) C09012.

T. A. Chiniforoush, A. Hadadi, Y. Kasesaz et al., Appl. Radiat. Isot. 170 (2021) 109596.

D-K. Yoon, J-Y. Jung, T. S. Suh, Appl. Phys. Let. 105 (2014) 223507.

S. J. Liu, D. Wu, T. X. Hu et al., Phys. Rev. Research 6 (2024) 013323.

International Commission on Radiological Protection (ICRP), Adult Reference Computational Phantom, in: Annal of the ICRP, ICRP Publication 110, 39 (2009).

S. Agostinelli, J. Allison, K. Amako et al., Nucl. Instrum. Methods Phys. Res., Sect. A, 506 (2003) 250.

J. Allison, K. Amako, J. Apostolakis et al., Nucl. Instrum. Methods Phys. Res., Sect. A, 835 (2016) 186.

J. Allison, K. Amako, J. Apostolakis et al., IEEE Trans. Nucl. Sci. 53(2006) 270.

M. A. Garabalino, E. M. Heber, A. M. Hughes et al., Radiat. Environ. Biophys. 52 (2013) 351.

H. G. Menzel, C. Clement, P. DeLuca, Annals of the ICRP 39 (2009) 1.

J. Valentin, Basic Anatomical and Physiological Datafor Use in Radiological Protection: Reference Values, in: Annals of the ICRP, ICRP Publication 89, Pergamon Press, Oxford(2002) 1.

J. Valentin, The 2007 Recommendations of the International Commission on Radiological Protection, in: Annals of the ICRP, ICRP Publication 103, Elsevier, Amsterdam (2007) 1.

A. A. Abojassim, D. J. Lawi and A. B. Hassan, Atom Indones. 50 (2024) 49. (in Indonesian)

T. Vermunt, The Feasibility of Proton Boron Capture Therapy: A computational Study, Master Thesis, Chemical Engineering, Delft University of Technology, Netherland (2019).

S. Kim, D-K. Yoon, H-B. Shin et al., J. Radioanal. Nucl. Chem. 316 (2018) 1059.




DOI: https://doi.org/10.55981/aij.2025.1541



Copyright (c) 2025 Atom Indonesia

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.