Determination of the Dosimetric Characteristics of BATAN’s 125I Source for Brachytherapy: An Experimental Study

K.Y.P. Sandy, S.A. Pawiro, D.S. Soejoko


125I brachytherapysources withlowphotonenergies have beenwidelyusedin treatingtumors.Accordingto American Association of Physicists in Medicine Task Group No. 43 (AAPMTG-43)recommendations,dosimetric characteristic ofthe newbrachytherapysources shouldbe determined before clinical use.Inthis study, dosimetric characteristic of 125Imanufacturedby BATAN have been determined through measurement by using Thermoluminescent Dosemeter (TLD) andgafchromic XR- QA2film.The radial dosefunctionmeasurements were performedat distances rangingfrom0.5to10cmfromthe source center.The anisotropyfunctions were measuredat distances of2,3,and5cmfromthe source center forangles ranging from0to 90degree inallquadrants.The results indicated that a doserate constants measured with TLD and film are 1.05± 8 % cGy.h-1.U-1and1.01±8 % cGy.h-1.U-1, respectively.The radial dosefunctiondecreasesalongwith the increasingdistance from source andmeetsthe 5thorderpolynomial equation. The anisotropyfunction resultshows thattheanisotropyindosedistributionincreasesalongthe source axis.Thismeasurement data areinagreementwith the previousstudy on EGSnrc Monte Carloresult andhave a similar patternwithIsoAidandGMS BT-125 commercial125Isource.


Dosimetry; Brachytherapy; Iodine-125; AAPM TG-43

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M.J. Zelefsky, D.A. Kuban, L.B Levy et al., Int. J. Radiat. Oncol. Biol. Phys. 67 (2007) 327.

L. Zhu, Y. Jiang, J. Wang et al., World J. Surg. Oncol. 11 (2013) 60.

Z. Xiang, G. Li, Z. Liu et al., Med. (Baltimore) 94 (2015) 2249.

C. Ren, R. Shi, L. Min et al., Clin. Oncol. (R. Coll. Radiol.) 26 (2014) 230.

Maiyesni, Mujinah, Witarti et al., Journal of Valence 3 (2013) 65. ( in Indonesian)

J. Pouliot and L. Beaulieu, Leibel and Phillips Textbook of Radiation Oncology, 3rd ed., Elsevier Inc. Saunders, Netherlands (2010) 224.

R. Deshmukh, A.N. Singh, M. Martinez et al., Side Effect of Drugs Annual. 38 (2016) 443.

R.G. Stock, N.N. Stone, M. Dahlal et al., Brachytherapy 1 (2002) 83.

R.S. Davies, T. Perrett, J. Powell et al., Med. Dosim. 41 (2016) 290.

M.J. Zelefsky, G.N. Cohen, A.S. Taggar et al., Pract. Radiat. Oncol. 7 (2017) 319.

N. Zhao, R. Yang, L. Ren et al., J. Appl. Clin. Med. Phys. 18 (2017) 49.

M.J. Rivard, B. Coursey, L. DeWerd et al., Med. Phys. 31 (2004) 633.

A.S. Meigooni, D.M. Gearheart and K. Sowards, Med. Phys. 27 (2000) 2168

S.H. Hosseini, M. Sadeghi and V. Ataeinia, Med. Phys. 36 (2009) 3080

M. Sadeghi, S.H. Hosseini and G. Raisali, Appl. Radiat. Isot. 66 (2008) 1431.

H. Safigholi, D. Sardari, J.S. Karimi et al., J. Appl. Clin. Med. Phys. 14 (2013) 4226.

B.P. McCabe, M. Speidel, T.L. Pike et al., Med. Phys. 38 (2011) 1919.

H-J. Selbach, H-M Kramer and W.S. Culberson, Metrologia 45 (2008) 422.

M. Golshan, I. Spadinger and N. Chang, Med. Phys. 43 (2016) 3008

P. Saidi, M. Sadeghi, A. Shirazi et al., Appl. Phys. Med. 28 (2012) 13.

J.F. Williamson, Med. Phys. 18 (1991) 776.

C.T. Budiantari, Determination of the Dosimetric Parameter of the 125I Brachytherapy Source Manufacturing by BATAN with Monte Carlo Simuation and Experimental Method, Thesis, Universitas Indonesia (2014). (in Indonesian)

L.A. DeWerd, G.S. Ibbott, A.S.Meigooni et al., Med. Phys. 38 (2011) 782.

P. Aryal, J.A. Molloy and M.J. Rivard, Med. Phys. 41 (2014) 021702.

M. Zehtabian, R Faghihi and S. Sina, Iran J. Radiat. Res. 7 (2010) 217.

P. Saidi, M. Sadeghi, S.H. Hosseini et al., J. Appl. Clin. Med. Phys. 12 (2011) 286.

A.S. Meigooni, J.L. Hayes, H. Zhang et al., Med. Phys. 29 (2002) 2152.


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